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BioMS

Biomolecular Mass Spectrometry
and proteomics

Heck Lab

Albert Heck

Professor

Albert Heck’s group focuses on advancing biomolecular mass spectrometry and proteomics to study proteins, protein complexes, and their modifications in biological systems. By developing and applying cutting-edge MS technologies and analytical workflows, the group investigates protein structure, interactions, and dynamics in health and disease, enabling deeper insights into cellular mechanisms and supporting biomedical and pharmaceutical research.

Awarded Grants

There are currently no awards noted down.

Group News

  • Albert J.R Heck is the recipient of the John B. Fenn Distinguished Contribution Award

    May 1, 2026

    Albert J.R Heck is the recipient of the John B. Fenn Distinguished Contribution Award, in recognition for his pioneering work in method development and applications of native mass spectrometry, especially for the study of the structure, function and assembly of very large macromolecular complexes, e.g. viruses and immune complexes. Read more on ASMS

    Read more →

  • A Single-Enzyme Shortcut to Antibody Sequencing

    March 13, 2026

    Highly efficient hyperthermal acidic
    proteases combined with hybrid-
    fragmentation schemes provide five
    times more unique peptide reads than
    trypsin or chymotrypsin, greatly boosting confidence in de novo sequencing. This approach enables confident de novo antibody sequencing based on a single
    LC-MS run.

    Read more →

Group Members

Albert Bondt

Project coordinator

Amber Rolland

General Member

Awital Bar Barroeta

General Member

Elena Giaretta

General Member

Henk van den Toorn

General Member

Iuliia Stroganova

General Member

Joshua Maliepaard

General Member

Laura Perez Paneda

General Member

Linus Wollenweber

General Member

Luc Marée

General Member

Nadia Mokiem

General Member

Rien Leuvenink

General Member

Serena Furlan

General Member

Shelley Jager

General Member

Sofia Kalaidopoulou Nteak

General Member

Tereza Kadavá

General Member

2026

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A Prototype timsOmni Platform Enables Confident Annotation of the Key Hypervariable CDR3 Regions of IgG Immunoglobulins Using Low- and High-Energy Electron-Based Fragmentation
Simon Ollivier, Dina Schuster, D. Van Rijswijck, Iuliia Stroganova, Athanasios Smyrnakis, Jan Fiala, Mariangela Kosmopoulou, Detlev Suckau, Stuart Pengelley, Oliver Raether, Jean‐François Greisch, Dimitris Papanastasiou, Albert J. R. Heck
Analytical Chemistry
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The 2025 Westlake Autumn Symposium for Al Proteomics and Virtual Cell
Rui Sun, Ruedi Aebersold, Qi Xiao, Matthias Mann, Yan Zhou, Albert J. R. Heck, Yingrui Wang, Uwe Völker, Xue Cai, C. Boone, Zizhuo Zhou, Ming Li, Zhen Dong, Brenda Andrews, Shuaiyao Wang, Joseph Schacherer, Connie R. Jiménez, Bernd Wollscheid, Liang Yue, Ben C. Collins, Heng Jiang, Dong Wang, Liujia Qian, Jia-Xing Yue, Yingying Sun, Edouard C. Nice, Xiaofan Zhang, Yasset Perez-Riverol, A. S. Jun, Chris Sander, Henning Hermjakob, Wout Bittremieux, Wilson Goh Wen Bin, Ge Gao, Peijie Zhou, Siqi Sun, Han Wen, Ziyan Xu, Tiannan Guo
Genomics Proteomics & Bioinformatics
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Expanding Glycopeptide Identification with Match-Between-Glycans in FragPipe
Jiechen Shen, Daniel A. Polasky, Shelley Jager, Fengchao Yu, Albert J. R. Heck, Karli R. Reiding, Alexey I. Nesvizhskii
bioRxiv (Cold Spring Harbor Laboratory)
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Spectral Quality-Guided Optimization of Hybrid EAciD Fragmentation on the ZenoTOF 7600 System Enables Efficient Characterization of the Serum N -Glycoproteome
Shelley Jager, Tatiana M. Shamorkina, Sibylle Heidelberger, Patrick Pribil, Douwe Schulte, Karli R. Reiding, Albert J.R. Heck
Analytical Chemistry
AI‐driven antibody design from an antigen sequence
Pavel Sinitcyn, Albert J. R. Heck
Vita
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Structural domain plasticity drives Zn( ii ) distribution and buffering in metallothionein-3
Manuel David Peris‐Díaz, Eduard H.T.M. Ebberink, Jan Fiala, Albert J. R. Heck, Artur Krężel
Chemical Communications

2025

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Uncovering the link between ATP synthase and the TCA cycle by crosslinking mass spectrometry
Laura Pérez Pañeda, Jelena Misic, Tereza Kadavá, Nils‐Göran Larsson, Albert J. R. Heck
bioRxiv (Cold Spring Harbor Laboratory)Preprint
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Widespread Fab-arm exchange affects all endogenous serum IgG4
Linus Wollenweber, Albert Bondt, Gestur Vidarsson, Maartje G. Huijbers, Albert J. R. Heck
Nature Communications
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The ferroform and glycoform landscape of human milk lactoferrin dissected through hybrid mass spectrometric approaches
Jing Zhu, Julia Bauzá‐Martinez, Joost W. Gouw, Xianfeng Zhao, Albert J. R. Heck, Bernd Stahl, Karli R. Reiding, Kelly A. Dingess
Frontiers in Nutrition
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Structural promiscuity in the human circulatory IgA1 clonal repertoire
Amber D. Rolland, Sofia Kalaidopoulou Nteak, Gestur Vidarsson, Albert Bondt, Albert J. R. Heck
Proceedings of the National Academy of Sciences
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Immunoglobulin sub-class levels define inter-donor plasma variability: a longitudinal dual-lab study
Stephan Michalik, Sofia Kalaidopoulou Nteak, Nicolas Drouin, Manuela Gesell Salazar, Elke Hammer, Vishnu M. Dhople, Silva Holtfreter, Stefan Weiß, Henk van den Toorn, Barbara M. Bröker, Grażyna Domańska, Uwe Völker, Albert J. R. Heck
bioRxiv (Cold Spring Harbor Laboratory)Preprint
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A Universal Spectrum Annotator for Complex Peptidoforms in Mass Spectrometry-Based Proteomics
Douwe Schulte, Rien Leuvenink, S. Jäger, Albert J. R. Heck, Joost Snijder
Analytical Chemistry
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Fucosylation limits ADCC in clinically used anti‐RhD monoclonal antibodies
Gabriela Koike, Albert Bondt, Douwe Schulte, Rien Leuvenink, Dirk Jan Mons, Peter C. Ligthart, E. J. T. Verweij, Albert J. R. Heck, C. Ellen van der Schoot, Gestur Vidarsson
Transfusion
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Isotype conversion of Staphylococcal-specific IgG into IgM broadens the reactivity to other bacterial pathogens
Remy M. Muts, Astrid Hendriks, Josefien W. Hommes, Max L.B. Grönloh, Douwe J. Dijkstra, Carla J. C. de Haas, Piet C. Aerts, Eduard H.T.M. Ebberink, Albert J. R. Heck, Zhen Wang, Haoru Zhuang, Jeroen D. C. Codée, Bas G. J. Surewaard, Dani A. C. Heesterbeek, Nina M. van Sorge, Suzan H. M. Rooijakkers
Cell Reports Medicine
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Extreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport
Daniele Bizzarri, Erik B. van den Akker, Marcel Reinders, René Pool, Marian Beekman, Nico Lakenberg, Nicolas Drouin, Kelly E. Stecker, Albert J. R. Heck, Edward F. Knol, Jeannette M. Vergeer, M. Arfan Ikram, Mohsen Ghanbari, Alain J. van Gool, Joris Deelen, Bbmri-Nl, Dorret I. Boomsma, P. Eline Slagboom
Immunity & Ageing

View Albert Heck on ORCID →