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BioMS

Biomolecular Mass Spectrometry
and proteomics

Heck Lab

Albert Heck

Professor

Albert Heck’s group focuses on advancing biomolecular mass spectrometry and proteomics to study proteins, protein complexes, and their modifications in biological systems. By developing and applying cutting-edge MS technologies and analytical workflows, the group investigates protein structure, interactions, and dynamics in health and disease, enabling deeper insights into cellular mechanisms and supporting biomedical and pharmaceutical research.

Awarded Grants

There are currently no awards noted down.

Group News

  • A Single-Enzyme Shortcut to Antibody Sequencing

    March 13, 2026

    Highly efficient hyperthermal acidic
    proteases combined with hybrid-
    fragmentation schemes provide five
    times more unique peptide reads than
    trypsin or chymotrypsin, greatly boosting confidence in de novo sequencing. This approach enables confident de novo antibody sequencing based on a single
    LC-MS run.

    Read more →

Group Members

Henk van den Toorn

General Member

2026

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The 2025 Westlake Autumn Symposium for Al Proteomics and Virtual Cell
Rui Sun, Ruedi Aebersold, Qi Xiao, Matthias Mann, Yan Zhou, Albert J. R. Heck, Yingrui Wang, Uwe Voelker, Xue Cai, C. Boone, Zizhuo Zhou, Ming Li, Zhen Dong, Brenda Andrews, Shuaiyao Wang, Joseph Schacherer, Connie R. Jiménez, Bernd Wollscheid, Liang Yue, Ben C. Collins, Heng Jiang, Dong Wang, Liujia Qian, Jia-Xing Yue, Yingying Sun, Edouard C. Nice, Xiaofan Zhang, Yasset Perez-Riverol, A. S. Jun, Chris Sander, Henning Hermjakob, Wout Bittremieux, Wilson Goh Wen Bin, Ge Gao, Peijie Zhou, Siqi Sun, Han Wen, Ziyan Xu, Tiannan Guo
Genomics Proteomics & Bioinformatics
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Expanding Glycopeptide Identification with Match-Between-Glycans in FragPipe
Jiechen Shen, Daniel A. Polasky, Shelley Jager, Fengchao Yu, Albert J. R. Heck, Karli R. Reiding, Alexey I. Nesvizhskii
bioRxiv (Cold Spring Harbor Laboratory)
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Spectral Quality-Guided Optimization of Hybrid EAciD Fragmentation on the ZenoTOF 7600 System Enables Efficient Characterization of the Serum N -Glycoproteome
Shelley Jager, Tatiana M. Shamorkina, Sibylle Heidelberger, Patrick Pribil, Douwe Schulte, Karli R. Reiding, Albert J.R. Heck
Analytical Chemistry
AI‐driven antibody design from an antigen sequence
Pavel Sinitcyn, Albert J. R. Heck
Vita
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Structural domain plasticity drives Zn(II) distribution and buffering in metallothionein-3
Manuel David Peris-Diaz, Eduard H.T.M. Ebberink, Jan Fiala, Albert J. R. Heck, Artur Krężel
Chemical Communications

2025

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Uncovering the link between ATP synthase and the TCA cycle by crosslinking mass spectrometry
Laura Pérez Pañeda, Jelena Misic, Tereza Kadavá, Nils‐Göran Larsson, Albert J. R. Heck
bioRxiv (Cold Spring Harbor Laboratory)Preprint
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Widespread Fab-arm exchange affects all endogenous serum IgG4
Linus Wollenweber, Albert Bondt, Gestur Vidarsson, Maartje G. Huijbers, Albert J. R. Heck
Nature Communications
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The ferroform and glycoform landscape of human milk lactoferrin dissected through hybrid mass spectrometric approaches
Jing Zhu, Julia Bauzá‐Martinez, Joost W. Gouw, Xianfeng Zhao, Albert J. R. Heck, Bernd Stahl, Karli R. Reiding, Kelly A. Dingess
Frontiers in Nutrition
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Structural promiscuity in the human circulatory IgA1 clonal repertoire
Amber D. Rolland, Sofia Kalaidopoulou Nteak, Gestur Vidarsson, Albert Bondt, Albert J. R. Heck
bioRxiv (Cold Spring Harbor Laboratory)Preprint
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Immunoglobulin sub-class levels define inter-donor plasma variability: a longitudinal dual-lab study
Stephan Michalik, Sofia Kalaidopoulou Nteak, Nicolas Drouin, Manuela Gesell Salazar, Elke Hammer, Vishnu M. Dhople, Silva Holtfreter, Stefan Weiß, Henk van den Toorn, Barbara M. Bröker, Grażyna Domańska, Uwe Völker, Albert J. R. Heck
bioRxiv (Cold Spring Harbor Laboratory)Preprint
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A prototype timsOmni platform enables confident annotation of key hypervariable regions of IgG immunoglobulins using low- and high-energy electron-based fragmentation
Simon Ollivier, Dina Schuster, Danique M.H. van Rijswijck, Iuliia Stroganova, Athanasios Smyrnakis, Jan Fiala, Mariangela Kosmopoulou, Detlev Suckau, Stuart Pengelley, Oliver Raether, Jean‐François Greisch, Dimitris Papanastasiou, Albert J. R. Heck
bioRxiv (Cold Spring Harbor Laboratory)Preprint
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A Universal Spectrum Annotator for Complex Peptidoforms in Mass Spectrometry-Based Proteomics
Douwe Schulte, Rien Leuvenink, S. Jäger, Albert J. R. Heck, Joost Snijder
Analytical Chemistry
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Fucosylation limits ADCC in clinically used anti‐RhD monoclonal antibodies
Gabriela Koike, Albert Bondt, Douwe Schulte, Rien Leuvenink, Dirk Jan Mons, Peter C. Ligthart, E. J. T. Verweij, Albert J. R. Heck, C. Ellen van der Schoot, Gestur Vidarsson
Transfusion
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Epigenetic risk stratification in juvenile myelomonocytic leukemia by targeted methylation analysis of the BMP4 locus
Foued Ghanjati, Albert J. R. Heck, Dirk Lebrecht, Peter Nöllke, Felicia Andresen, Natalia Rotari, Michael Schoof, Maximilian Schönung, Daniel B. Lipka, Michael Dworzak, Barbara De Moerloose, Martina Suková, Henrik Hasle, Kirsi Jahnukainen, Andrea Malone, Riccardo Masetti, Jochen Buechner, Marek Ussowicz, Albert Català, Dominik Turkiewicz, Válerie de Haas, Markus Schmugge, Miriam Erlacher, Charlotte M. Niemeyer, Christian Flotho
Clinical Epigenetics
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Isotype conversion of Staphylococcal-specific IgG into IgM broadens the reactivity to other bacterial pathogens
Remy M. Muts, Astrid Hendriks, Josefien W. Hommes, Max L.B. Grönloh, Douwe J. Dijkstra, Carla J. C. de Haas, Piet C. Aerts, Eduard H.T.M. Ebberink, Albert J. R. Heck, Zhen Wang, Haoru Zhuang, Jeroen D. C. Codée, Bas G. J. Surewaard, Dani A. C. Heesterbeek, Nina M. van Sorge, Suzan H. M. Rooijakkers
Cell Reports Medicine

View Albert Heck on ORCID →