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BioMS

Biomolecular Mass Spectrometry
and proteomics

Snijder Lab

Joost Snijder

Assistant Professor

Our group uses structural proteomics techniques to study virus-host interactions. With mass spectrometry and cryo electron microscopy we develops new approaches to sequence antibodies and study how they neutralize viral infections at the molecular level. Likewise, we study how viruses evade antiviral immunity, and how they enter and remodel their host cell to replicate.

Awarded Grants

There are currently no awards noted down.

Group News

  • Chemists break barriers and open up super-resolution molecule mass analysis

    January 8, 2026

    By modifying and boosting lab equipment, a team of chemists are able to measure individual molecules with unprecedented precision. This precision relates to being able to tell that one single sugar grain is missing from a full 1 kilogram bag of sugar. Their massive resolution upgrading will benefit the fabrication of vaccines and molecular vectors […]

    Read more →

Group Members

Adinda Kok

General Member

Corinna Plitt

General Member

Cynthia Kelley

General Member

Douwe Schulte

General Member

Frerik Nagel

General Member

Sabrina Krepel

General Member

Stef Remmelzwaal

General Member

Tatiana Shamorkina

General Member

2026

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Integrative structure of norovirus NS3 suggests a role in RNA transport
Meryl Haas, T. Hoeksma, Jake T. Mills, Cynthia Kelley, A. K. Das, K. Shyam, Robin Veenstra, Owen Byford, Henrietta Hóf, Coco Niemel, Tim Donselaar, Ieva Drulyte, Frank J. M. van Kuppeveld, David Dulin, Joost Snijder, Morgan R. Herod, Daniel L. Hurdiss
Nature Communications
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Reference-free protein sequencing by consensus assembly of redundant de novo peptide reads
Alfred Nilsson, Emil Sporre, Douwe Schulte, Joost Snijder, Fredrik Edfors, Lukas Käll
bioRxiv (Cold Spring Harbor Laboratory)Preprint
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Cetacean coronavirus spikes highlight S glycoprotein structural plasticity
Ruben J. G. Hulswit, Tatiana M. Shamorkina, Joline van der Lee, Floor Rosman, Lisanne S. Wetzels, Frank J. M. van Kuppeveld, Joost Snijder, Berend‐Jan Bosch, Daniel L. Hurdiss
PLoS Pathogens
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Structure of SARS-CoV-2 spike in complex with its co-receptor the neuronal cell adhesion protein contactin 1
Sabrina T. Krepel, Daniel L. Hurdiss, Berend‐Jan Bosch, Joost Snijder, Bert J. C. Janssen
bioRxiv (Cold Spring Harbor Laboratory)Preprint
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Host cell remodeling via cyclin dependent kinases drives Ebola virus replication and transcription
Tatiana M. Shamorkina, Danni Snikkers, Albert J. R. Heck, Joost Snijder
bioRxiv (Cold Spring Harbor Laboratory)Preprint
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Plasma proteomics identifies early markers of endothelial and inflammatory activation associated with dengue disease severity in children
Tatiana M. Shamorkina, Sofia Kalaidopoulou Nteak, Sokchea Lay, Ashwin Adrian Kallor, Sowath Ly, Veasna Duong, Albert J. R. Heck, Tineke Cantaert, Joost Snijder
medRxivPreprint
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Deep coverage and extended sequence reads obtained with a single archaeal protease expedite de novo protein sequencing by mass spectrometry
Laura Pérez Pañeda, Tereza Kadavá, Tatiana M. Shamorkina, Douwe Schulte, Patrick A. Pribil, Sibylle Heidelberger, Allison Michele Narlock-Brand, Steven M. Yannone, Joost Snijder, Albert J. R. Heck
Cell Systems
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The glycan shield of alphaherpesvirus glycoprotein B modulates host co-receptor binding
Sabrina T. Krepel, Francine R. Ianiski, Bert J. C. Janssen, Joost Snijder
bioRxiv (Cold Spring Harbor Laboratory)Preprint

2025

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Structural and immunological characterization of the H3 influenza hemagglutinin during antigenic drift
Rebeca de Paiva Fróes Rocha, Ilhan Tomris, Charles A. Bowman, Emma Stevens, Jason Kantorow, Corinna M. Plitt, Weiwei Peng, Svearike Oeverdieck, Thales Galdino Andrade, James A. Ferguson, Diana D. Jung, Rafael Elias Marques, Sander Herfst, Joost Snijder, Srirupa Chakraborty, Alba Torrents de la Peña, Zachary T. Berndsen, Robert P. de Vries, Andrew B. Ward
Nature Communications
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A Universal Spectrum Annotator for Complex Peptidoforms in Mass Spectrometry-Based Proteomics
Douwe Schulte, Rien W. Leuvenink, Shelley Jager, Albert J. R. Heck, Joost Snijder
Analytical Chemistry
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Stabilized Full-Length Measles Fusion Protein Elicits Potent Immunity and Protection In Vivo
Dawid S. Zyla, Gillian Zipursky, Roberta Della Marca, Davide Lacarbonara, Gele Niemeyer, Weiwei Peng, Camilla Predella, Kyle N. Stearns, Cameron Leedale, Jonathan L Miller, Daniel Tay, Jonathan Kao, Marissa Danielle Acciani, Laura Di Clemente, Anirban Das, Diptiben V. Parekh, Rubén Díaz-Avalos, Gael G. McGill, N. Valerio Dorrello, Kathryn M. Hastie, Christopher A. Alabi, Joost Snijder, Anne Moscona, Alexander L. Greninger, Stefan Niewiesk, Erica Ollmann Saphire, Matteo Porotto
bioRxiv (Cold Spring Harbor Laboratory)Preprint
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Structural Basis for Postfusion-Specific Binding to the Respiratory Syncytial Virus F Protein by the Canonical Antigenic Site I Antibody 131–2a
Weiwei Peng, Marta Šiborová, Xuesheng Wu, Wenjuan Du, Douwe Schulte, Matti F. Pronker, Cornelis A. M. de Haan, Joost Snijder
ACS Infectious Diseases
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Simultaneous polyclonal antibody sequencing and epitope mapping by cryo electron microscopy and mass spectrometry – a perspective
Douwe Schulte, Marta Šiborová, Lukas Käll, Joost Snijder
eLifePreprint
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Broadly neutralizing antibodies targeting pandemic GII.4 variants or seven GII genotypes of human norovirus
Juyeon Park, Lisa C. Lindesmith, Adam S. Olia, Verónica Costantini, Paul D. Brewer-Jensen, Michael L. Mallory, Cynthia Kelley, Ed Satterwhite, Victoria Longo, Yaroslav Tsybovsky, Tyler Stephens, Jeffrey Marchioni, Christina A. Martins, Yimin Huang, Ridhi Chaudhary, Mark R. Zweigart, Samantha R. May, Yaoska I Reyes, Becca A. Flitter, Jan Vinjé, Sean N. Tucker, Gregory C. Ippolito, Jason J. Lavinder, Joost Snijder, Peter D. Kwong, George Georgiou, Ralph Steven Baric
Science Translational Medicine

2024

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A neutralizing antibody prevents postfusion transition of measles virus fusion protein
Dawid S. Zyla, Roberta Della Marca, Gele Niemeyer, Gillian Zipursky, Kyle N. Stearns, Cameron Leedale, Elizabeth B. Sobolik, Heather Callaway, Chitra Hariharan, Weiwei Peng, Diptiben V. Parekh, Tara C. Marcink, Rubén Díaz-Avalos, Branka Horvat, Cyrille Mathieu, Joost Snijder, Alexander L. Greninger, Kathryn M. Hastie, Stefan Niewiesk, Anne Moscona, Matteo Porotto, Erica Ollmann Saphire
Science

View Joost Snijder on ORCID →