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Snijder Lab

Joost Snijder

Assistant Professor

Our group uses structural proteomics techniques to study virus-host interactions. With mass spectrometry and cryo electron microscopy we develops new approaches to sequence antibodies and study how they neutralize viral infections at the molecular level. Likewise, we study how viruses evade antiviral immunity, and how they enter and remodel their host cell to replicate.

Awarded Grants

There are currently no awards noted down.

Group News

  • Chemists break barriers and open up super-resolution molecule mass analysis

    January 8, 2026

    By modifying and boosting lab equipment, a team of chemists are able to measure individual molecules with unprecedented precision. This precision relates to being able to tell that one single sugar grain is missing from a full 1 kilogram bag of sugar. Their massive resolution upgrading will benefit the fabrication of vaccines and molecular vectors […]

    Read more →

Group Members

Adinda Kok

General Member

Corinna Plitt

General Member

Cynthia Kelley

General Member

Douwe Schulte

General Member

Frerik Nagel

General Member

Sabrina Krepel

General Member

Stef Remmelzwaal

General Member

Tatiana Shamorkina

General Member

2026

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The glycan shield of alphaherpesvirus glycoprotein B modulates host co-receptor binding
Sabrina T. Krepel, Francine R. Ianiski, B.J.C. Janssen, Joost Snijder

2025

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Structural and immunological characterization of the H3 influenza hemagglutinin during antigenic drift
Rebeca de Paiva Fróes Rocha, Ilhan Tomris, Charles A. Bowman, Eugene S. Stevens, Jason Kantorow, Corinna M. Plitt, Weiwei Peng, Svearike Oeverdieck, Tarcísio Andrade, James A. Ferguson, Diana D. Jung, Rafael Elias Marques, Sander Herfst, Joost Snijder, Srirupa Chakraborty, Alba Torrents de la Peña, Zachary T. Berndsen, Robert P. de Vries, Andrew B. Ward
Nature Communications
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A Universal Spectrum Annotator for Complex Peptidoforms in Mass Spectrometry-Based Proteomics
Douwe Schulte, Rien Leuvenink, S. Jäger, Albert J. R. Heck, Joost Snijder
Analytical Chemistry
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Stabilized Full-Length Measles Fusion Protein Elicits Potent Immunity and Protection In Vivo
Dawid Zyla, Gillian Zipursky, Roberta Della Marca, Davide Lacarbonara, Gele Niemeyer, Weiwei Peng, Camilla Predella, Kyle Stearns, Cameron Leedale, Jonathan Miller, Daniel Tay, Jia‐Horng Kao, Marissa D. Acciani, Laura Di Clemente, Anirban Das, Diptiben Parekh, Ruben Diaz Avalos, Gaël McGill, N. Valerio Dorrello, Kathryn M. Hastie, Christopher A. Alabi, Joost Snijder, Anne Moscona, Alexander L. Greninger, Stefan Niewiesk, Erica Ollmann Saphire, Matteo Porotto
Preprint
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Structural Basis for Postfusion-Specific Binding to the Respiratory Syncytial Virus F Protein by the Canonical Antigenic Site I Antibody 131–2a
Weiwei Peng, Marta Šiborová, Xuesheng Wu, Wenjuan Du, Douwe Schulte, Matti F. Pronker, Cornelis A. M. de Haan, Joost Snijder
ACS Infectious Diseases
Integrative Structure of Norovirus NS3 Suggests a Role in RNA Transport
Meryl Haas, Jake T. Mills, Cynthia Kelley, Arnab Das, Henrietta Hóf, Coco Niemel, Tim Donselaar, Ieva Drulyte, Frank J. M. van Kuppeveld, David Dulin, Joost Snijder, Morgan R. Herod, Daniel L. Hurdiss
Preprint
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Deep Coverage and Extended Sequence Reads Obtained with a Single Archaeal Protease Expedite de novo Protein Sequencing by Mass Spectrometry
Tatiana M. Shamorkina, Laura Pérez Pañeda, Tereza Kadavá, Douwe Schulte, Patrick Pribil, Sibylle Heidelberger, Allison Michele Narlock-Brand, Steven M. Yannone, Joost Snijder, Albert J. R. Heck
Preprint
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Cetacean coronavirus spikes highlight S glycoprotein structural plasticity
Ruben J. G. Hulswit, Tatiana M. Shamorkina, Joline van der Lee, Floor Rosman, Lisanne S. Wetzels, Frank J. M. van Kuppeveld, Joost Snijder, Berend‐Jan Bosch, Daniel L. Hurdiss
Preprint
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Simultaneous polyclonal antibody sequencing and epitope mapping by cryo electron microscopy and mass spectrometry
Douwe Schulte, Marta Šiborová, Lukas Käll, Joost Snijder
eLife
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Broadly neutralizing antibodies targeting pandemic GII.4 variants or seven GII genotypes of human norovirus
Juyeon Park, Lisa C. Lindesmith, Adam S. Olia, Verónica Costantini, Paul D. Brewer-Jensen, Michael L. Mallory, Cynthia Kelley, Ed Satterwhite, Valerie A. Longo, Yaroslav Tsybovsky, Tyler Stephens, Jeffrey Marchioni, Christina A. Martins, Yimin Huang, Ridhi Chaudhary, Mark R. Zweigart, Samantha R. May, Yaoska Reyes, Becca A. Flitter, Jan Vinjé, Sean N. Tucker, Gregory C. Ippolito, Jason J. Lavinder, Joost Snijder, Peter D. Kwong, George Georgiou, Ralph S. Baric
Science Translational Medicine

2024

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A neutralizing antibody prevents postfusion transition of measles virus fusion protein
Dawid Zyla, Roberta Della Marca, Gele Niemeyer, Gillian Zipursky, Kyle Stearns, Cameron Leedale, Elizabeth B. Sobolik, Heather Callaway, Chitra Hariharan, Weiwei Peng, Diptiben Parekh, Tara C. Marcink, Ruben Diaz Avalos, Branka Horvat, Cyrille Mathieu, Joost Snijder, Alexander L. Greninger, Kathryn M. Hastie, Stefan Niewiesk, Anne Moscona, Matteo Porotto, Erica Ollmann Saphire
Science
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A Handle on Mass Coincidence Errors in De Novo Sequencing of Antibodies by Bottom-up Proteomics
Douwe Schulte, Joost Snijder
Journal of Proteome Research
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Structural Basis for Recognition of the FLAG-tag by Anti-FLAG M2
J. Wouter Beugelink, Els Sweep, B.J.C. Janssen, Joost Snijder, Matti F. Pronker
Journal of Molecular Biology
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Reverse-engineering the anti-MUC1 antibody 139H2 by mass spectrometry–based de novo sequencing
Weiwei Peng, Koen C. A. P. Giesbers, Marta Šiborová, J. Wouter Beugelink, Matti F. Pronker, Douwe Schulte, John Hilkens, B.J.C. Janssen, Karin Strijbis, Joost Snijder
Life Science Alliance
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Filamentous fungus-produced human monoclonal antibody provides protection against SARS-CoV-2 in hamster and non-human primate models
Franziska Kaiser, Mariana González-Hernández, Nadine Krüger, Ellinor Englund, Wenjuan Du, Anna Z. Mykytyn, Matthijs P. Raadsen, Mart M. Lamers, Francine R. Ianiski, Tatiana M. Shamorkina, Joost Snijder, Federico Armando, Georg Beythien, Małgorzata Ciurkiewicz, Tom Schreiner, Eva Gruber-Dujardin, Martina Bleyer, Olga Batura, Lena Erffmeier, Rabea Hinkel, Cheila Rocha, Monica Mirolo, Dubravka Drabek, Berend‐Jan Bosch, Mark Emalfarb, Noelia Valbuena, Ronen Tchelet, Wolfgang Baumgärtner, Markku Saloheimo, Stefan Pöhlmann, Frank Grosveld, Bart L. Haagmans, Albert Osterhaus
Nature Communications

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