Reiding Lab – Biomolecular Mass Spectrometry and Proteomics

Karli Reiding

Assistant Professor

Glycoproteomics & Glycoprotein Analysis

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2026

Expanding Glycopeptide Identification with Match-Between-Glycans in FragPipe

Jiechen Shen, Daniel A. Polasky, Shelley Jager, Fengchao Yu, Inge Huitinga, Karli R. Reiding, Alexey I. Nesvizhskii

Spectral Quality-Guided Optimization of Hybrid EAciD Fragmentation on the ZenoTOF 7600 System Enables Efficient Characterization of the Serum N -Glycoproteome

Shelley Jager, Tatiana M. Shamorkina, Sibylle Heidelberger, Patrick Pribil, Douwe Schulte, Karli R. Reiding, Inge Huitinga

Analytical Chemistry

2025

The ferroform and glycoform landscape of human milk lactoferrin dissected through hybrid mass spectrometric approaches

Jing Zhu, Julia Bauzá‐Martinez, Joost W. Gouw, Xianfeng Zhao, Albert J. R. Heck, Bernd Stahl, Karli R. Reiding, Kelly A. Dingess

Frontiers in Nutrition

Overglycosylation introduces local changes in triple helix alignment in collagen type I fibril structure

Luco Rutten, Judith M. Schaart, Liline A.S. Fermin, J. J. Xu, Marit de Beer, Robin H.M. van der Meijden, Karli R. Reiding, Anat Akiva, Nico A. J. M. Sommerdijk, Elena Macías‐Sánchez

Preprint

P12-25 Integrating in vitro digestion and peptidomics into novel food allergenicity assessment: A study on Clostridium tyrobutyricum biomass

Vaios D. Fytsilis, Rong Ji, Karli R. Reiding, Achim Heck, Frederik‐Jan van Schooten, Alie de Boer, Misha F. Vrolijk

Toxicology Letters

Mannan interference and purification efficiency in downstream processing of precision-fermented milk proteins from Komagataella phaffii

Aryo D. Nugroho, Rensong Ji, Yi Ling Chin, Albert J. R. Heck, Karli R. Reiding, Remko M. Boom, Julia K. Keppler

Future Foods

In-depth plasma N-glycoproteome profiling using narrow-window data-independent acquisition on the Orbitrap Astral mass spectrometer

S. Jäger, Martin Zeller, Anna Pashkova, Douwe Schulte, Eugen Damoc, Karli R. Reiding, Alexander Makarov, Albert J. R. Heck

Nature Communications

Engineering of anticancer human immunoglobulin A equipped with albumin for enhanced plasma half-life

Simone Mester, Chilam Chan, Marta Lustig, Stian Foss, J.H. Marco Jansen, Marie Leangen Herigstad, Mitchell Evers, Jeannette Nilsen, Karli R. Reiding, J Damen, Renate Burger, Algirdas Grevys, Bjørn Dalhus, Thomas Valerius, Inger Sandlie, Jeanette H.W. Leusen, Jan Terje Andersen

PNAS Nexus

Affinity-based covalent sialyltransferase probes enabled by ligand-directed chemistry

Jun Yang Ong, Erianna I. Alvarado-Melendez, Joshua C. L. Maliepaard, Karli R. Reiding, Tom Wennekes

Chemical Science

2024

Spatial Organization of the Sperm Cell Glycoproteome

Rensong Ji, Riccardo Zenezini Chiozzi, Henk van den Toorn, Miguel Ricardo Leung, Tzviya Zeev‐Ben‐Mordehai, Nathan D. Burke, Elizabeth G. Bromfield, Karli R. Reiding, Albert J. R. Heck

Molecular & Cellular Proteomics

Human IgG Subclasses Differ in the Structural Elements of Their N-Glycosylation

Wei‐Wei Wang, Joshua C. L. Maliepaard, Timon Damelang, Gestur Vidarsson, Albert J. R. Heck, Karli R. Reiding

ACS Central Science

Narrow window data-independent acquisition on the Orbitrap Astral Mass Spectrometer enables fast and deep coverage of the plasma glycoproteome

S. Jäger, Martin Zeller, Anna Pashkova, Douwe Schulte, Eugen Damoc, Karli R. Reiding, Alexander Makarov, Albert J. R. Heck

Preprint

LacdiNAc to LacNAc: remodelling of bovine α-lactalbumin N-glycosylation during the transition from colostrum to mature milk

Inge Gazi, Karli R. Reiding, André Groeneveld, Jan Bastiaans, Thom Huppertz, Albert J. R. Heck

Glycobiology

The pleiotropic phenotype of FlbA of Aspergillus niger is explained in part by the activity of seven of its downstream-regulated transcription factors

Xiaoyi Chen, Juan P. Moran Torres, Peter Jan Vonk, J Damen, Karli R. Reiding, Jan Dijksterhuis, Luis G. Lugones, Han A. B. Wösten

Fungal Genetics and Biology

Complex N -glycans are important for interspecies transmission of H7 influenza A viruses

Cindy M. Spruit, Diana I. Palme, Tiehai Li, María Ríos Carrasco, Alba Gabarroca García, Igor R. Sweet, Maryna Kuryshko, Joshua C. L. Maliepaard, Karli R. Reiding, David Scheibner, Geert‐Jan Boons, Elsayed M. Abdelwhab, Robert P. de Vries

Journal of Virology

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